(Sorry, no names on the forum.) AC is the ultimate go-to person for HSV WB interpretation. Reach the lab by calling SCH and asking for the Virology lab and then to speak with a senior clinician - or ask to talk directly with the lab supervisor, whose initials are AC. Although listed as a University of Washington lab, the virology lab where WB testing is done is located at Seattle Children's Hospital. When the next repeat results are in, if they are anything other than definite positive or negative, ask your doctor to consider speaking direclty to the lab. In any case, your doctor is doing exactly the right thing. My understanding is that most indeterminate HSV-2 WB results are truly negative. Which leaves the confusing Western blot results. With your low values and the negative inhibition test, it's unlikely you have HSV-2. Although that test is technically positive when the numerical value is 1.1 or more, most truly infected people have results of 3.5 or more. But can you tell me exactly what IgG test(s) were done? The Focus HerpeSelect test (done at Quest Laboratory, among others) and Trinity Biotech Captia test (done at Labcorp, the other large multistate lab) are the usual ones, but HerpeSelect has been studied the most. As for HSV-2, most likely you are not infected. Around 10-15% of people with HSV-1 have negative IgG antibody tests, so nothing unusal there. First, the easy part: The Western blot results indicate you definitely have HSV-1. Handsfield, for allowing me the opportunity to post on your board on this issue. The fact that yours was negative is, I think, really hopeful about this being a false positive. the problem with false positives that plague the ELISA also plague the inhibition assay. Rarely, do I see a positive ELISA on the herpeselect and negative inhibition assay. The fact that you have a negative inhibition assay is also very hopeful. I can't say that the results of this study will be a 100% clarification, just perhaps one more piece of the puzzle to confirm or not confirm your infection. We are trying all we can do to find out a way to sort out these kinds of test results as we know that people want to move on and live lives that are full and rewarding, sexually, and these test results can get in the way of all of that. I know this must be so frustrating for you! You are definitely not alone in this situation. When the study starts, we would get you a consent form and arrange to have your blood drawn and sent to us for this purpose. Taulbee a message indicating you are interested in participating. If you are interested, please call and leave Dr. However, we are starting a study this summer of a different test called a flow cytometry test, to look at those indeterminate western blot folks to try a different way to sort through confusing test results. Good afternoon, I really do agree with Hunter on this - I think it is very unlikely that you are infected with HSV 2 but with an indeterminate western blot, that is truly hard to say for certain.
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